Seminar Speaker Series – Prof. Rubén Fernández-Busnadiego (18. 03. 2021)

Lecture by Prof. Rubén Fernández-Busnadiego from University Medical Center Göttingen, DE, entitled „Unraveling the structure of toxic protein aggregates in situ“ from the CAPSID Seminar Speaker Series, will take place on 18 March 2021 at 2 p.m. via online broadcasting via the ZOOM application.

RESEARCH FOCUS:

Unravelling the structure of toxic protein aggregates in situ.

ANNOTATION:

Protein aggregation is a hallmark of many neurodegenerative diseases, including Huntington’s, Parkinson’s and amyotrophic lateral sclerosis. However, the mechanisms linking aggregation to neurotoxicity remain poorly understood, partly because only limited information is available on the native structure of protein aggregates inside cells. We address this pressing issue utilizing the latest developments in cryo-electron tomography (cryo-ET). We prepare thin lamellas of vitrified cells containing protein aggregates using cryo-focused ion beam, and subsequently image them in three dimensions by cryo-ET. This allows us to analyse aggregate structure within pristinely preserved cellular environments and at molecular resolution. Here, I will discuss how our latest results shed new light into the cellular mechanisms of neurodegeneration.

More information about lecture and registration on the project web site: https://capsid.vbcf.ac.at/events/ 

ANNOTATION and SUBMISSION DATA OF THE LECTURE (pdf)

Funding programme of the CAPSID project: Interreg V-A Slovakia-Austria

 Organizers: