Seminar Speaker Series – Dr. Claudio Alfieri (10. 06. 2021)

Lecture by Dr. Claudio Alfieri from The Institute for Cancer Research, London, UK entitled „Molecular snapshots of cell cycle control by cryo-EM“ from the CAPSID Seminar Speaker Series, will take place on 10 June 2021 at 2 p.m. via online broadcasting via the ZOOM application.

AREAS OF EXPERTISE:

Dr. Claudio Alfieri is Team Leader of the Molecular Mechanisms of Cell Cycle Regulation Team at the Institute for Cancer Research (ICR). His research focuses on how the cell cycle is regulated by large macromolecular complexes during cell division, cell cycle exit and re-entry.

SEMINAR ANNOTATION:

The maintenance of genome stability in mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an APC/C inhibitor. Unattached kinetochores control MCC assembly by catalysing a change in topology of the β-sheet of Mad2, an MCC subunit. Disassembly of free MCC, required for SAC inactivation and chromosome segregation, is an ATP-dependent process driven by the AAA+ ATPase TRIP13. In combination with the SAC antagonist p31comet, TRIP13 remodels C-Mad2 into inactive open Mad2 (O-Mad2). Here, we present a mechanism to explain how TRIP13-p31 disassembles the MCC. Our study provides insights into how specific substrates are recruited to AAA+ ATPases through adaptor proteins and suggests a model of how translocation through the axial pore of AAA+ ATPases is coupled to protein remodelling.

More information about lecture and registration on the project web site: https://capsid.vbcf.ac.at/events/ 

ANNOTATION and SUBMISSION DATA OF THE LECTURE (pdf)

Funding programme of the CAPSID project: Interreg V-A Slovakia-Austria

 Organizers: