AKTUÁLNE PROJEKTY / RUNNING PROJECTS

APVV-21-0108 (2022-2026) – CoViD – Antiviral drugs against COVID-19: Design, synthesis and biological activity testing of specific inhibitors of viral proteases of coronavirus SARS-CoV-2 (PI za BMC: Nemčovičová)

APVV-19-0376 (2020-2024) – BIOTREAT – Development of bioimmunotherapeutics inspired by viral tricks: TREATing despite the TRICKs (PI: Nemčovičová)

APVV-20-0243 (2021-2025) – Glyco4Bio – Biochip systems for targeted glycan analysis of biomarkers for biomedical and biotechnological applications (PI za BMC: Nemčovičová)

Interreg SK-AT NFP305010V235 (2021) – CAPSID – Scientific capacity building in biomedical research through scientific exchange and co-development of research services (PI: Nemčovičová)

VEGA 2/0026/22 (2022-2025) – GlycoOFFviro – The study of viral interactions underlying regulation of the immunological synapse for the development of a novel immunotherapeutic concept based on viral tricks (PI: Nemčovičová)

VEGA 2/0108/22 (2022-2025) Innate antiviral defense responses of selected human skin cells to tick-borne encephalitis virus and their modulation by bioactive substances in tick saliva (PI: Štibrániová)

VEGA 2/0063/21 (2021-2024) Herpesviral immunomodulators as novel candidates in therapy of cancer and inflammatory diseases (PI: Lopušná)

VEGA 2/0031/20 (2020-2023) Vplyv proteínu NS1 a infekčnej dávky vírusu chrípky na patogenitu a vrodenú imunitnú odpoveď v mozgoch, srdciach a slezinách infikovaných myší (PI: Betáková)

VEGA 2/0172/19 (2019-2022) Izolácia, identifikácia a charakterizácia transformujúci rastový faktor-beta 1 viažúcej molekuly v extraktoch slinných žliaz kliešťov (PI: Bartíková)

ÚSPEŠNE UKONČENÉ PROJEKTY / SUCESSFULY FINISHED PROJECTS

PP-COVID-20-0010 (2020-2022) – CoViDRUGS – New antiviral drugs: design, synthesis and activity evaluation of specific inhibitors of viral proteases of SARS-CoV-2 (PI za BMC: Nemčovičová)

APVV-14-0839 (2015-2019) – IMUNOMOD – Immune modulation by cytomegalovirus and its immunotherapeutic potential (PI: Nemčovičová)

APVV-15-0474 (2016-2020) – The identification of EBHS virus and selected pathogens as possible cause of the European brown hare (Lepus europaeus) population decline in Slovakia (PI za BMC: Kúdelová)

MVTS-V112-CAPSID (2018-2021) – CAPSID – Podpora medzinárodnej vedecko-technickej spolupráce (PI: Nemčovičová)

SASPRO-0003/01/02 (2015-2018) – IMMUNOVIROLOGICS: Immune modulation by HCMV and its immunotherapeutic potential (PI: Nemčovičová)

VEGA-2/0047/18 (2018-2021) – Monitoring the effect of immunomodulators in ticks saliva on innate antiviral skin immunity (PI: Štibrániová)

VEGA-2/0020/18 (2018-2021) – Molecular immunerecognition of viral UL144 glycoprotein by endogenous signaling molecules and their clinical potential (PI: Nemčovičová)

VEGA-2/0014/16 (2016-2019) – The role of cytokines/chemokines in the immune response to influenza A infection (PI: Betáková)

VEGA-2/0087/17 (2017-2020) – Imunomodulatory properties of the murine herpesvirus M3 protein and the role of ticks in herpesvirus circulation in nature (PI: Kúdelová)

VEGA-2/0199/15 (2015-2018) – Effect of salivary gland extracts derived from different tick species on induction and biological activity of interferon-lambda 1 (PI: Bartíková)

VYBRANÉ PUBLIKÁCIE / SELECTED PUBLICATIONS

(súčasní a bývalí členovia tímu sú uvedení modrou farbou)

HANCKOVÁ, Miriam – BETÁKOVÁ, Tatiana. Pandemics of the 21st Century: The Risk Factor for Obese People. In Viruses, 2022, vol. 14, no. 1, art. no. 25. (2021: 1.463 – SJR, Q1 – SJR).

2021

LENHARTOVÁ, Simona – NEMČOVIČ, Marek – ŠEBOVÁ, Radka – BENKO, Mário – ZAJONC, Dirk – NEMČOVIČOVÁ, Ivana. Molecular characterization of the native (non-linked) CD160–HVEM protein complex revealed by initial crystallographic analysis. In Crystals, 2021, vol. 11, no. 7, art. no. 820 [14] p. (2020: 2.589 – IF, Q2 – JCR, 0.538 – SJR, Q2 – SJR).

LOPUŠNÁ, Katarína – LENHARTOVÁ, Simona – NEMČOVIČOVÁ, Ivana. Biological testing of novel viral protease inhibitors against SARS-CoV-2 in mammalian model cell line VERO-E6. In European Journal of Immunology. – Weinheim : Wiley-VCH Verlag, 2021, vol. 51, suppl. 1, p. 382. (2020: 5.532 – IF, Q2 – JCR, 2.272 – SJR, Q1 – SJR).

NEMČOVIČOVÁ, Ivana – LENHARTOVÁ, Simona – ŠKRABANA, Rostislav – BENKO, Mário – NEMČOVIČ, Marek. Molecular insights into host-virus interaction of human and rhesus cytomegalovirus UL144 mediated by immune checkpoint BTLA and CD160. In Journal of immunology, 2021, vol. 206, no. 1. suppl. 1. (2020: 5.422 – IF, Q2 – JCR, 2.737 – SJR, Q1 – SJR).

LENHARTOVÁ, Simona – školiteľ: NEMČOVIČOVÁ, Ivana. The molecular and structural characterization of viral glycoprotein UL144 (humanus vs. simia) and its binding to human cell receptor CD160: Dizertačné doktorandské práce (PhD.,Dr.) Bratislava: Univerzita Komenského v Bratislave, Prírodovedecká fakulta, 2021. 148 s.

LENHARTOVÁ, Simona – NEMČOVIČ, Marek – ŠEBOVÁ, Radka – BENKO, Mário – ZAJONC, D.M. – NEMČOVIČOVÁ, Ivana. Molecular characterization of the native (non-linked) CD160-HVEM protein complex revealed. In Acta Crystallographica A, 2021, vol. A77, c1106, PS-41-4. (2020: 2.290 – IF, Q2 – JCR, 0.742 – SJR, Q1 – SJR).

BEŇOVÁ, Kristína – školiteľ: BETÁKOVÁ, Tatiana. Úloha cytokínov v imunitnej odpovedi na infekciu vírusom chrípky: Dizertačné doktorandské práce (PhD.,Dr.). Bratislava : Univerzita Komenského v Bratislave, Prírodovedecká fakulta, 2021. 88 s.

2020

BARTÍKOVÁ, Pavlína – KAZIMÍROVÁ, Mária – ŠTIBRÁNIOVÁ, Iveta. Ticks and the effects of their saliva on growth factors involved in skin wound healing. In Journal of Venom Research, 2020, vol. 10 iss., p. 45-52. ISSN 2044-0324.

BENKO, Mário – LENHARTOVÁ, Simona – KEMPOVÁ, Viera – BETÁKOVÁ, Tatiana – KÚDELOVÁ, Marcela. Chemokine-binding proteins encoded by herpesviruses. In Acta Virologica, 2020, vol. 64, no. 2, p. 233-244. (2019: 0.793 – IF, Q4 – JCR, 0.358 – SJR, Q3 – SJR).

TURIANOVÁ, Lucia – LACHOVÁ, Veronika – BEŇOVÁ, Kristína – KOSTRÁBOVÁ, A. – BETÁKOVÁ, Tatiana. Influenza A virus lacking the effector and C terminal domains of NS1 protein induces cytokines associated with high pathogenicity in mice. In Acta Virologica, 2020, vol. 64, no. 1, p. 78-87. (2019: 0.793 – IF, Q4 – JCR, 0.358 – SJR, Q3 – SJR).

BENKO, Mário – školiteľ: NEMČOVIČOVÁ, Ivana. Biological and binding properties of the clinically significant human cytomegalovirus UL144 glycoprotein: Dizertačné doktorandské práce (PhD.,Dr.) Bratislava: Univerzita Komenského v Bratislave. Prírodovedecká fakulta, 2020. 126 s.

NEMČOVIČOVÁ, Ivana – BENKO, Mário – LENHARTOVÁ, Simona – KEMPOVÁ, Viera – NEMČOVIČ, Marek. New insights into the role of N-glycosylation involved in molecular immune checkpoint regulation by human cytomegalovirus glycoproteins with the implication in cancer therapy. In Journal of Immunology, 2020, vol. 204, suppl. 1, p. 248.19. (2019: 4.886 – IF, Q2 – JCR, 2.509 – SJR, Q1 – SJR).

KEMPOVÁ, Viera – LENHARTOVÁ, Simona – BENKO, Mário – NEMČOVIČ, Marek – KÚDELOVÁ, Marcela – NEMČOVIČOVÁ, Ivana. The power of human cytomegalovirus (HCMV) hijacked UL/b functions lost in vitro. In Acta Virologica, 2020, vol. 64, no. 2, p. 117-130. (2019: 0.793 – IF, 0.358 – SJR, Q3 – SJR).

BEŇOVÁ, Kristína – HANCKOVÁ, Miriam – KOČI, Kamila – KÚDELOVÁ, Marcela – BETÁKOVÁ, Tatiana. T cells and their function in the immune response to viruses. In Acta Virologica, 2020, vol. 64, no. 2, p. 131-143. (2019: 0.793 – IF, Q4 – JCR, 0.358 – SJR, Q3 – SJR).

2019

BITRA, Aruna – NEMČOVIČOVÁ, Ivana – PICARDA, Gaelle – DOUKOV, Tzanko – WANG, J. – BENEDICT, C.A. – ZAJONC, Dirk. Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell lymphocyte attenuator. In Journal of Biological Chemistry, 2019, vol. 294, no. 27, p. 10519-10529. (2018: 4.106 – IF, 2.403 – SJR, Q1 – SJR, karentované – CCC).

ŠTIBRÁNIOVÁ, Iveta – BARTÍKOVÁ, Pavlína – HOLÍKOVÁ, Viera – KAZIMÍROVÁ, Mária. Deciphering biological processes at the tick-host interface opens new strategies for treatment of human diseases. In Frontiers in Physiology, 2019, vol. 10, art. 830. (2018: 3.201 – IF, Q2 – JCR, 1.153 – SJR, Q2 – SJR). ISSN 1664-042X.

ŠEBOVÁ, Radka – BAUEROVÁ-HLINKOVÁ, Vladena – BECK, K – NEMČOVIČOVÁ, Ivana – BAUER, Jacob – KÚDELOVÁ, Marcela. Residue mutations in murine herpesvirus 68 immunomodulatory protein M3 reveal specific modulation of chemokine binding. In Frontiers: Microbiology, 2019, vol. 9, art. no. 210. (2018: 3.518 – IF, Q2 – JCR, 1.541 – SJR, Q1 – SJR).

LABUDOVÁ, Martina – ZDURIENČÍKOVÁ, Martina – FABIANOVÁ, Andrea – BARÁTOVÁ, Magdaléna – DITTE, Peter – RADVÁK, Peter – NEMČOVIČOVÁ, Ivana – PASTOREKOVÁ, Silvia – PASTOREK, Jaromír. Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX. In Acta Virologica, 2019, vol. 63, no. 2, p. 169-185. (2018: 0.554 – IF, 0.283 – SJR, Q3 – SJR)

NEMČOVIČOVÁ, Ivana – NEMČOVIČ, Marek – BENKO, Mário – LENHARTOVÁ, Simona – HOLÍKOVÁ, Viera – ZAJONC, Dirk. Analysis of cytomegalovirus immune evasion protein UL144 glycosylation profile revealed its role in immune recognition. In Acta Crystallographica A, 2019, vol. 75, p. E92-E92. (2018: 1.878 – IF, Q2 – JCR, 7.285 – SJR, Q1 – SJR).

KÚDELOVÁ, Marcela – ŠTIBRÁNIOVÁ, Iveta. Murine gammaherpesvirus 68 (MHV-68), a newly discovered tick borne virus : open access peer-reviewed chapter. In Ticks and Tick-Borne Pathogens : open access peer-reviewed edited volume. – London, United Kingdom : IntechOpen, 2019, chapter 6, p. 1-18. ISBN 978-1-78985-766-5.

TURIANOVÁ, Lucia – LACHOVÁ, Veronika – SVETLÍKOVÁ, Darina – KOSTRÁBOVÁ, A. – BETÁKOVÁ, Tatiana. Comparison of cytokine profiles induced by nonlethal and lethal doses of influenza A virus in mice. In Experimental and Therapeutic Medicine, 2019, vol. 18, p. 4397-4405. (2018: 1.448 – IF, Q4 – JCR, 0.488 – SJR, Q2 – SJR).

2018

NEMČOVIČOVÁ, Ivana – BENKO, Mário – NEMČOVIČ, Marek. Site-specific analysis of UL144 protein from human cytomegalovirus highlights its role in virus-mediated immune evasion. In Acta Crystallographica A, 2018, vol. A74, p. e189-e190. (2017: 7.930 – IF, Q1 – JCR, 5.990 – SJR, Q1 – SJR).

ŠVANČAROVÁ, Petra – BETÁKOVÁ, Tatiana. Conserved methionine 165 of matrix protein contributes to the nuclear import and is essential for influenza A virus replication. In Virology Journal, 2018, vol. 15 no. 187, p. 1-9. (2017: 2.465 – IF, Q3 – JCR, 1.053 – SJR, Q2 – SJR).

KÚDELOVÁ, Marcela – JÁNOŠOVÁ, Monika – BELVONČÍKOVÁ, Petra. First detection of murine herpesvirus 68 in adult Ixodes ricinus ticks. Folia Microbiologica, 2018, 1-5 (1.521 – IF2016)

KÚDELOVÁ, Marcela – SLOVÁK, Mirko – KABÁT, Peter – DERKA, T. – ŠTEVOVE, B. – BOHUŠ, M – VRBOVÁ, Michaela. A survey on murine gammaherpesvirus 68 in ticks collected in Slovakia. Acta virologica 62: 98 – 103, 2018 (0.673 – IF2016)

KAZIMÍROVÁ, Mária – BARTÍKOVÁ, Pavlína – ŠTIBRÁNIOVÁ, Iveta. Tick-Borne Viruses and Host Skin Interface. In Skin and Arthropod Vectors. – GB : Elsevier, 2018, p. 325-384. ISBN 978-0-12-811436-0.

HOLÍKOVÁ, Viera – ŠTIBRÁNIOVÁ, Iveta – BARTÍKOVÁ, Pavlína – SLOVÁK, Mirko – KAZIMÍROVÁ, Mária. Ixodid tick salivary gland extracts suppress human transforming growth factor-β1 triggered signalling pathways in cervical carcinoma cells. In Biologia, 2018, vol. 73, iss. 11, p. 1109-1122. (2017: 0.696 – IF, Q4 – JCR, 0.299 – SJR, Q3 – SJR).

2017

ŠEBOVÁ, Radka – LENHARTOVÁ, Simona – ŠTIBRÁNIOVÁ, Iveta – NEMČOVIČOVÁ, Ivana -BELVONČÍKOVÁ, Petra – KÚDELOVÁ, Marcela. A Deletion of Signal Peptide in Recombinant Murine Gamma-herpesvirus68 M3 Protein Enhances its Binding Affinity to CCL5 Chemokine and Increases its Yield from Insect Cells. J Infect Dis Ther 2017, 6:1 (1.650 – IF2016)

HAJNICKÁ, Valéria – KÚDELOVÁ, Marcela – ŠTIBRÁNIOVÁ, Iveta – SLOVÁK, Mirko – BARTÍKOVÁ, Pavlína – HALÁSOVÁ, Zuzana – PANČÍK, Peter – BELVONČÍKOVÁ, Petra – VRBOVÁ, Michaela – HOLÍKOVÁ, Viera – HAILS, R.S. – NUTTALL, Patricia A. Tick-borne transmission of murine gammaherpesvirus 68. Front. Cell. Infect. Microbiol. 2017, vol. 7, article 458. (4.300 – IF2016)

BETÁKOVÁ, Tatiana – KOSTRÁBOVÁ, A – LACHOVÁ, Veronika – TURIANOVÁ, Lucia. Cytokines induced during influenza virus infection. In Current Pharmaceutical Design, 2017, vol. 23, p. 2616-22. (2.611 – IF2016)

ŠEDÝ J. – BALMERT WARE B. – SMITH W. – NEMČOVIČOVÁ, Ivana – NORRIS P. – MILLER B. – AIVAZIAN D. – WARE C.A. – Herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator. Journal of Biological Chemistry, 2017 (5.078 -IF2016)

KAZIMÍROVÁ, Mária – THANGAMANI, Saravanan – BARTÍKOVÁ, Pavlína – HERMANCE, Meghan – HOLÍKOVÁ, Viera – ŠTIBRÁNIOVÁ, Iveta – NUTTALL, Patricia A. Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface. Front. Cell. Infect. Microbiol. 2017, vol. 7, article: 339. 21 pp. (4.300 – IF2016)

LACHOVÁ, Veronika – ŠKORVANOVÁ, Lucia – SVETLÍKOVÁ, Darina – TURIANOVÁ, Lucia – KOSTRÁBOVÁ, A. – BETÁKOVÁ, Tatiana. Comparison of transcriptional profiles of interferons, CXCL10 and RIG-1 in influenza infected A549 cells stimulated with exogenous interferons. In Acta Virologica, 2017, vol. 61, no. 2, p. 183-190. (0.673 – IF2016)

KÚDELOVÁ, Marcela – JÁNOŠOVÁ, M. – VRBOVÁ, Michaela – MATÚŠKOVÁ, Radka – SLOVÁK, Mirko – BELVONČÍKOVÁ, Petra. Detection of Transcripts and an Infectious Dose of Murine Gammaherpesvirus 68 in Dermacentor reticulatus Ticks. In Journal of Infectious Diseases and Therapeutics, 2017, vol. 5. (1.650 – IF2016)

DRAGÚŇOVÁ, Jana – KABÁT, Peter – BABÁL, Pavel – MRÁZOVÁ, H. – BOHÁČ, M. – KRAJČIOVÁ, Ľ. – KOLLER, J. Development of a new method for the preparation of an acellular allodermis, quality control and cytotoxicity testing. In Cell tissue banking, 2017, vol. 18, no. 2, p. 153-166. (1.331 – IF2016)

MRÁZOVÁ, Veronika – KÚDELOVÁ, Marcela – SMOLINSKÁ, Miroslava – NOVÁKOVÁ, Eva – ŠUPOLÍKOVÁ, Miroslava – VRBOVÁ, Michaela – GOLAIS, František. Transformation of cells by photoinactivated murine gamma herpesvirus 68 during nonproductive and quiescent infection. In Intervirology, 2017, vol. 60, no. 1-2, p. 61-68. (1.292 – IF2016)

BARTÍKOVÁ, Pavlína – HOLÍKOVÁ, Viera – KAZIMÍROVÁ, Mária – ŠTIBRÁNIOVÁ, Iveta. Tick-borne viruses. Rewiev. In Acta Virologica, 2017, vol. 61, no. 4, p. 413 – 427. (0.673 – IF2016)

LENČEŠOVÁ, Ľubomíra – SZADVARI, I. – BABULA, P. – KUBICKOVA, J. – CHOVANCOVÁ, Barbora – LOPUŠNÁ, Katarína – REŽUCHOVÁ, Ingeborg – NOVAKOVA, Z. – KRIŽANOVÁ, Oľga – NOVÁKOVÁ, M. Disruption of dopamine D1/D2 receptor complex is involved in the function of haloperidol in cardiac H9c2 cells. In Life Sciences, 2017, vol. 191, p. 186-194. (2016: 2.936 – IF, 1.093 – SJR, Q1 – SJR).

KOSTRÁBOVÁ, A. – PASTOREKOVÁ, Silvia – BETÁKOVÁ, Tatiana. Biosyntéza vírusov. I. diel. 1. vyd. Bratislava : Univerzita Komenského v Bratislave : Vydavateľstvo UK, 2017. 135 s. ISBN 978-80-223-4402-9.

LACHOVÁ, Veronika – školiteľ: BETÁKOVÁ, Tatiana. Využitie NS1 delečných mutantov vírusu chrípky v terapii : dizertačné doktorandské práce (PhD.,Dr.). Bratislava : Univerzita Komenského v Bratislave, Prírodovedecká fakulta : Biomedicínske centrum SAV, 2017. 158 s.

2016

ALTEEN, M.G. – OEHLER, V. – NEMČOVIČOVÁ, Ivana – WILSON, I.B.H. – VOCADLO, V.J. – GLOSTER, T.M. Mechanism of Human Nucleocytoplasmic Hexosaminidase D. In Biochemistry, 2016, vol. 55, p. 2735-2747. (2.876 – IF2015)

VRBOVÁ, Michaela – BELVONČÍKOVÁ, Petra – KOVAĽOVÁ, A. – MATÚŠKOVÁ, Radka – SLOVÁK, Mirko – KÚDELOVÁ, Marcela. Molecular detection of murine gammaherpesvirus 68 (MHV-68) in Haemaphysalis concinna ticks collected in Slovakia. In Acta Virologica : international journal, 2016, vol. 60, p. 426-428. (1.222 – IF2015)

LACHOVÁ, Veronika – SVETLÍKOVÁ, Darina – GOLAIS, František – ŠUPOLÍKOVÁ, Miroslava – TURIANOVÁ, Lucia – BETÁKOVÁ, Tatiana. Transforming Activity of Murine Herpesvirus 68 Putative Growth Factor Is Related to the Ability to Change Cytoskeletal Structure. In Intervirology: The journal of virology division, 2016, vol. 59, p. 137-142. (1.822 – IF2015)

VÁCLAV, Radovan – BETÁKOVÁ, Tatiana – ŠVANČAROVÁ, Petra – PEREZ-SERRANO, Jorge – CRIADO-FORNELIO, A. – ŠKORVANOVÁ, Lucia – FRANCISCO, V. Nest ecology of blood parasites in the European roller and its ectoparasitic carnid fly. In Experimental Parasitology, 2016, vol. 165, p. 71-80. (1.623 – IF2015)

KLEMPAIOVÁ, M. – DRAGÚŇOVÁ, Jana – KABÁT, Peter – HNÁTOVÁ, M. – KOLLER, J. – BAKOŠ, Dušan. Cytotoxicity testing of a polyurethane nanofiber membrane modified with chitosan/b-cyclodextrin/berberine suitable for wound dressing application: evaluation of biocompatibility. In Cell and Tissue Banking, 2016, vol. 17, p. 665-675. (1.248 – IF2015)

REINERT, L.S. – LOPUŠNÁ, Katarína – WINTHER, H. – SUN, Ch. – THOMSEN, M.K. – NANDAKUMAR, R. – MOGENSEN, T.H. – MEYER, Morten – VAEGTER, Ch. – NYENGAARD, J.R. – FITZGERALD, K.A. – PALUDAN, S.R. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. In Nature Communications, 2016, vol. 7, p. 13348-13348. (2015: 11.329 – IF, 6.287 – SJR, Q1 – SJR).

Fuchsberger, N – HAJNICKÁ, Valéria – BARTÍKOVÁ, Pavlína; Patent Number: US 07439229, Patent Assignee: Evolutec Limited: Cytokine activity regulator molecules from tick salivary glands. U.S. Patent and Trademark Office.

NEMČOVIČOVÁ, Ivana – Benedict, CA – Zajonc, DM, Verma, S – U.S. patent US2017088600-A1; Composition for designing compound, protein or peptide that interacts with TNF-related apoptosis inducing ligand (TRAIL)-R2 receptor, comprises TRAIL-R2 receptor or its fragment bound to ligand in crystalline form.

NEMČOVIČOVÁ, Ivana – Benedict, CA – Zajonc, DM – U.S. patent US2014134647-A1; Composition useful in antiviral drug for e.g. providing antiinflammatory response, comprises TRAIL-R2 receptor or fragment of TRAIL-R2 receptor bound to ligand in crystalline form.

Rajčáni, J – Matis, J – Leško, J – Leššo, J – KÚDELOVÁ, Marcela. Autorské osvedčenie vynálezu č. 265536, udelené Federálnym úradom pre vynálezy: Subjednotková vakcína proti rekurentnému herpesu a spôsob jej prípravy.