The Clinical Research Unit (CRU) has had more than 40 years of tradition in clinical research in the field of diabetes, endocrinology, cardiovascular and autonomic nervous system, stress and autoimmunity, approved health-care provider under the Act No. 578/2004. In the Department is working experienced, GCP-certified staff with strong clinical and academic background – 5 senior staff MD/PhDs.

Two inpatient intensive care beds, 4 specialized outpatient rooms (metabolic, cardiovascular, autonomic and small surgery e.g. biopsy) are available at the CRU. Routinely used methods include insulin clamps, indirect calorimetry, bicycle spiroergometry, drug testing, tilt table, Valsalva maneuver, tissue biopsy, microdialysis, blood sampling/processing/storage, cell isolation/sorting/FACS, standard hypothermia, bed-rest, social stress and others.

Selected Clinical Trials Performed at the CRU:

• Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance (MS-MIDY) NCT03052595
• Effect of Specific Diet and Physical Activity on Weight and/or Fat Loss NCT02325804
• Genetics and Mechanisms of Rheumatoid Arthritis (RASGENAS) NCT01788098
• Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker (ADIRAS) NCT01444833
• Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs (Brain-Muscle) NCT02253732
• Effect of Carnosine on Diabetes and Cardiovascular Risk Factors (Carnorisk) NCT02011100
• Effects of Growth Hormone Supplementation to Adults With Growth Hormone Deficient on Metabolism and Adipose Tissue Molecular Phenotype (GHAT) NCT01616095