Lecture by Dr. Joachim Goedhart from University of Amsterdam, NL entitled „Imaging G-protein signaling with genetically encoded fluorescent probes“ from the CAPSID Seminar Speaker Series, will take place on 15 April 2021 at 2 p.m.via online broadcasting via the ZOOM application.
RESEARCH INTEREST:
All living creatures are composed of small (< 1 mm) entities, known as cells. During their life, cells undergo changes such as growth, differentiation and movement. These changes are steered by molecules in the extracellular environment. The translation of extracellular, chemical information into a cellular state change is a process known as signal transduction. Signal transduction is mediated by a diverse set of signaling molecules located inside the cell, i.e. enzymes, second messengers, lipids, scaffolds, and transcription factors. It is increasingly recognised that spatial and temporal aspects of molecular interactions and activity are key for correct cellular responses.
„Our research aims at understanding the spatial and temporal aspects of molecular activities that drive cellular processes.“
ANNOTATION:
We focus on signaling events initiated by a class of seven-transmembrane spanning receptors, the G-protein coupled receptor (GPCR) family. To examine the molecular events that occur during signal transduction, we engineer and employ genetically encoded fluorescent biosensors. These versatile tools enable quantitative, functional imaging of molecular interactions, protein activities, or second messenger concentration in single living cells. The functional imaging studies will improve our understanding of how cells respond to their environment. Several classes of optical probes are used, e.g., FRET biosensors, relocation-based probes, and intensity-based probes that use circular permuted fluorescent proteins. I will discuss the engineering and application of fluorescent proteins and biosensors in the context of GPCR and G-protein signalling in single cells.
More information about lecture and registration on the project web site: https://capsid.vbcf.ac.at/events/
ANNOTATION and SUBMISSION DATA OF THE LECTURE (pdf)
Funding programme of the CAPSID project: Interreg V-A Slovakia-Austria
Organizers:
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